Interleukin-23 in the Pathogenesis and Treatment of Psoriasis

Skin Therapy Letter-Family Practice Edition

关键词: cytokine;    interleukin-23;    IL-23;    guselkumab;    tildrakizumab;    Th17;    psoriasis;   

DOI  :  

学科分类：医学（综合）

来源: Skin Therapy Letter-Family Practice Edition

【 摘 要 】

In the past three decades, major advances have been made in understanding the pathogenesis of psoriasis. The currently accepted theory is that T-cell mediated immune dysregulation triggers keratinocyte hyperproliferation in psoriasis. Recent research indicates that the Th17/interleukin (IL)-23 pathway plays a prominent role in the amplification phase of psoriasis. The discovery of the Th17/ IL-23 pathway provides targets for new drug development. This review focuses on the role of IL-23 in psoriasis pathogenesis and the current therapies targeting IL-23 that are in clinical trials.

【 授权许可】

Unknown