Pimecrolimus 1% Cream for the Treatment of Atopic Dermatitis

Skin Therapy Letter-Family Practice Edition

关键词: atopic dermatitis;    calcineurin inhibitor;    pimecrolimus;   

DOI  :  

学科分类：医学（综合）

来源: Skin Therapy Letter-Family Practice Edition

【 摘 要 】

Atopic dermatitis is a highly pruritic inflammatory disorder of the skin characterized byonset in infancy or childhood and a chronically relapsing course. Mainstay treatments areemollients and topical corticosteroids, but the latter are limited by side-effects from longtermuse. Pimecrolimus is an ascomycin macrolactam derivative and a calcineurin inhibitorthat targets T-cell activation but does not inhibit antigen-presenting cells in the skin. Inmultiple clinical trials comprising more than 19,000 patients, pimecrolimus cream has beenshown to be very effective in suppressing atopic dermatitis and to have an excellent safetyprofile. This has also been shown in long-term studies (>2 years) and by postmarketingexperience.

【 授权许可】

Unknown