Sézary syndrome, Kaposi sarcoma and generalized dermatophytosis 15 years after sulfur mustard gas exposure

Journal of Dermatological Case Reports

Seyed Naser Emadi¹ 

[1] Skin Research Center, Mazandaran University of Medical Sciences, Sari, Iran

关键词: cutaneous T-cell lymphoma;    genotoxins;    genital;    Kaposi's sarcoma;    Sezary syndrome;    war;   

DOI  :  10.3315/jdcr.2012.1109

学科分类：皮肤病学

来源: Specjalisci Dermatolodz

【 摘 要 】

Background The relationship between compromised immune system and the development of malignancy, generalized dermatitis, and infection after sulfur mustard gas exposure has been established.Main observation We introduce a 58-year-old man with an abrupt, de novo and erythrodermic eruption in 2002 that was previously exposed to sulfur mustard during the Iran – Iraq war in 1987. Six weeks after the onset of diffuse eruption, he developed papules on the glans penis and generalized dermatophytosis. A biopsy of his eruption was consistent with cutaneous T-cell lymphoma/Sézary syndrome. A complete blood count demonstrated leukocytosis, eosinophilia and atypical lymphocytosis. Subsequently, Sézary syndrome was confirmed and T-cell count with increased CD4/CD8 in flow cytometry. The biopsy of his penile papules was consistent with Kaposi's sarcoma.Conclusion These findings suggest a causative relationship between sulfur mustard gas exposure, cutaneous T cell lymphoma and immune compromised state with opportunistic infections.

【 授权许可】

Unknown