Thiamine Deficiency and Delirium

Innovations in Clinical Neuroscience

Shagufta Jabeen¹  Narviar C. Barker¹  C. Freeman¹  William Richie¹  Rahn K. Bailey¹  Kenneth Osiezagha¹  Yetunde Olagbemiro¹  Shahid Ali¹  Sarbani Maitra¹ 

[1] All authors are from Department of Psychiatry and Behavioral Health, Meharry Medical College in Nashville, Tennessee.

关键词: Thiamine deficiency;    Kreb’s cycle;    delirium;    Wernicke’s encephalopathy;   

DOI  :  

学科分类：精神健康和精神病学

来源: Matrix Medical Communications, LLC

【 摘 要 】

Thiamine is an essential vitamin that plays an important role in cellular production of energy from ingested food and enhances normal neuronal actives. Deficiency of this vitamin leads to a very serious clinical condition known as delirium. Studies performed in the United States and other parts of the world have established the link between thiamine deficiency and delirium. This literature review examines the physiology, pathophysiology, predisposing factors, clinical manifestations (e.g., Wernicke’s encephalopathy, Wernicke-Korsakoff syndrome, structural and functional brain injuries) and diagnosis of thiamine deficiency and delirium. Current treatment practices are also discussed that may improve patient outcome, which ultimately may result in a reduction in healthcare costs.

【 授权许可】

Unknown