Obstructive Sleep Apnea and Depression: A Review

Innovations in Clinical Neuroscience

Imran S. Khawaja¹  Thomas D. Hurwitz¹  Shakir M. Ejaz¹  Subhash Bhatia¹ 

[1] Dr. Ejaz is from the Minnesota Regional Sleep Disorders Center, Hennepin County Medical Center, Minneapolis, Minnesota, and University of Minnesota, Minneapolis, Minnesota; Drs. Khawaja and Hurwitz are from Veterans Affairs Medical Center, Minneapolis, Minnesota, and University of Minnesota; and Dr. Bhatia is from the VA Medical Center, Omaha, Nebraska.

关键词: Obstructive sleep apnea;    OSA;    sleep disordered breathing;    depression;    CPAP;    continuous positive airway pressure;   

DOI  :  

学科分类：精神健康和精神病学

来源: Matrix Medical Communications, LLC

【 摘 要 】

Obstructive sleep apnea is a common sleep disorder associated with several medical conditions, increased risk of motor vehicle accidents, and overall healthcare expenditure. There is higher prevalence of depression in people with obstructive sleep apnea in both clinical and community samples. Many symptoms of depression and obstructive sleep apnea overlap causing under-diagnosis of obstructive sleep apnea in depressed patients. Sleep problems, including obstructive sleep apnea, are rarely assessed on a regular basis in patients with depressive disorders, but they may be responsible for antidepressant treatment failure. The mechanism of the relationship between obstructive sleep apnea and depression is complex and remains unclear. Though some studies suggest a mutual relationship, the relationship remains unclear. Several possible pathophysiological mechanisms could explain how obstructive sleep apnea can cause or worsen depression. Increased knowledge of the relationship between obstructive sleep apnea and depression might significantly improve diagnostic accuracy as well as treatment outcomes for both obstructive sleep apnea and depression.

【 授权许可】

Unknown