A Naturalistic, Single-blind Comparison of Rapid Dose Administration of Divalproex ER Versus Quetiapine in Patients with Acute Bipolar Mania

Innovations in Clinical Neuroscience

Barbara Galangue¹  Olga Becker¹  Allison Hadley¹  Kai MacDonald¹  David Feifel¹  Patrice Cobb¹  Ana Dinca¹  J. Cooper¹ 

[1] All from the Department of Psychiatry, University of California San Diego Medical Center, San Diego, California

关键词: Mania;    bipolar affective disorder;    quetiapine;    divalproex;   

DOI  :  

学科分类：精神健康和精神病学

来源: Matrix Medical Communications, LLC

【 摘 要 】

Objective: When treating acute bipolar mania, the speed of onset of anti-manic effects is crucial. Quetiapine and divalproex ER are widely used agents to treat acute mania. Rapid dose administration regimens for divalproex ER and for quetiapine have been described. We conducted a naturalistic, head-to-head, pilot study comparing the efficacy and safety of rapidly titrated divalproex ER and quetiapine in acutely manic inpatients, with the primary outcome being improvement within the first seven days.

【 授权许可】

Unknown