Focal Laser Ablation for Localized Prostate Cancer: Principles, Clinical Trials, and Our Initial Experience

Reviews in Urology

Neil Mendhiratta²  Herbert Lepor²  Ted Lee²  Dan Sperling¹ 

[1] Sperling Prostate Center,, New York, NY;Department of Urology, New York University School of Medicine,, New York, NY

关键词: Laser ablation;    Prostate cancer;    Focal therapy;    Targeted therapy;   

DOI  :  

学科分类：基础医学

来源: MedReviews, LLC

【 摘 要 】

Focal therapy of prostate cancer is an evolving treatment strategy that destroys a predefined region of the prostate gland that harbors clinically significant disease. Although long-term oncologic control has yet to be demonstrated, focal therapy is associated with a marked decrease in treatment-related morbidity. Focal laser ablation is an emerging modality that has several advantages, most notably real-time magnetic resonance imaging (MRI) compatibility. This review presents the principles of laser ablation, the role of multiparametric MRI for delineating the site of significant prostate cancer, a summary of published clinical studies, and our initial experience with 23 patients, criteria for selecting candidates for focal prostate ablation, and speculation regarding future directions.

【 授权许可】

Unknown