47,XYY Syndrome and Male Infertility

Reviews in Urology

Edmund Y Ko²  Ina W Kim¹  Arjun C Khadilkar¹  Edmund S Sabanegh, Jr¹ 

[1] Center for Male Fertility, Glickman Urological and Kidney Institute, Cleveland Clinic Foundation,, Cleveland, OH;Department of Urology, Loma Linda University,, Loma Linda, CA

关键词: Infertility syndromes;   

DOI  :  

学科分类：基础医学

来源: MedReviews, LLC

【 摘 要 】

Men with 47,XYY syndrome present with varying physical attributes and degrees of infertility. A retrospective chart review was performed on a male infertility and genetic anomaly database. Three patients with 47,XYY were found. Each presented with > 2 years of infertility. All were tall with elevated body mass indices. Scrotal findings ranged from normal to atrophic testicles. Semen analyses demonstrated oligospermia and varying endocrine profiles. Because of the diverse phenotype and potential lack of symptoms, identification and diagnosis of men with 47,XYY syndrome may be difficult. We recommend careful screening of 47,XYY patients and referral to primary physicians for long-term follow-up for increased incidence of health-related comorbidities.

【 授权许可】

Unknown