Regulation of Trophoblast Invasion: The Role of Matrix Metalloproteinases

Reviews in Obstetrics and Gynecology

Yan-hong Yu¹  Jia-Yu Zhu¹  Zhan-Jun Pang¹ 

[1] Department of Obstetrics & Gynecology, Nanfang Hospital of Southern Medical University,, Guangzhou 510515, China

关键词: Trophoblast invasion;    Placenta;    Matrix metalloproteinases;    Tissue inhibitors of metalloproteinases;   

DOI  :  

学科分类：医学（综合）

来源: MedReviews, LLC

【 摘 要 】

Pregnancy success is determined by a complex progress that includes trophoblast invasion and placentation. Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) are metal-dependent endopeptidases capable of degrading extracellular matrix, and appear to play a critical role in trophoblast invasion. This article reviews in detail the role of MMPs, TIMPs, and their regulators in the mechanism of trophoblast invasion in early human pregnancy.

【 授权许可】

Unknown