Surgical Debulking of Ovarian Cancer: What Difference Does It Make?

Reviews in Obstetrics and Gynecology

John O Schorge¹  Marcela G Del Carmen¹  Christopher McCann¹ 

[1] Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA

关键词: Ovarian cancer;    Primary debulking surgery;    Neoadjuvant chemotherapy;    Interval debulking surgery;    Secondary debulking surgery;   

DOI  :  

学科分类：医学（综合）

来源: MedReviews, LLC

【 摘 要 】

Three-quarters of women who are newly diagnosed with invasive epithelial ovarian cancer present with stage III to IV disease. Recent data on the efficacy of neoadjuvant chemotherapy have served to challenge the conventional dogma that the preferred initial treatment is surgical debulking. Most of these patients will achieve remission regardless of initial treatment, but 80% to 90% of patients will ultimately relapse. The timing and clinical benefit of a second debulking operation is even more contentious. This article focuses on the recent debate of when or if patients with ovarian cancer should undergo aggressive surgical resection of bulky disease.

【 授权许可】

Unknown