The Effect of KIO3 and KI Salt Towards Iodium Levels (I2) in Urine, Malondialdehyde (MDA) and The Histology of Thyroid Gland of Goitrogenic Rat

The Journal of Pure and Applied Chemistry Research

Chanif Mahdi¹  Risman Heli¹  Sasangka Prasetyawan¹ 

[1] Chemistry Department, Brawijaya University$$

关键词: Goitrogenic;    Iodium;    Malondialdehyde;    KIO3;    KI salt;    therapy;   

DOI  :  

来源: University of Brawijaya

【 摘 要 】

Goitrogenic substances can inhibit of iodine taking by the thyroid gland. Thus iodine concentration in thyroid gland will be low, and this phenomena is indicated by inflammation in the thyroid gland. Moreover, it can cause releaseing of an excessive amount of free radicals. This radicals, in the body, causes oxidative stress and also increase the levels of malondialdehyde (MDA). This is also as an indicator for lipid peroxidation and the decreasing of urinary iodine excretion levels (EIU). The treatment with KIO 3 and KI salt was intended to study the level of supplementation of iodine (I 2 ) toward level of MDA in serum and histological description of rat’s thyroid gland. The MDA levels was determined through TBA test (Thio Barbituric Acid), meanwhile the histological pattern of  rat thyroid gland was determined by Hematoxylen-Eosin staining (HE). The results indicated both of KIO 3 and KI salt significantly (p<0.01) reduced MDA level in the serum. Treatment with KIO 3 salt gave 33.62% while KI salt slightly higher (37,02%). In addition, both of treaments displayed an recovering effect in thyroid gland.

【 授权许可】

Unknown