Journal of Clinical and Basic Cardiology | |
Saving Lives Post-MI: Highly Purified Omega-3 PUFAs for the Prevention of Sudden Death | |
Verboom C-N1  Jäger B1  Rupp H1  | |
[1] $$ | |
关键词: Arrhythmie; GISSI; Kardiologie; Myokardfunktion; Omega-3-Fettsäure; plötzlicher Herztod; arrhythmia; clinical trials; GISSI; highly purified omega-3 PUFAs; myocardial infarction; sudden death; | |
DOI : | |
学科分类:心脏病和心血管学 | |
来源: Krause & Pachernegg GmbH | |
【 摘 要 】
Opportunities still exist to improve prognosis and survival after myocardial infarction (MI). In particular there is a substantial mortality attributable to sudden death, a mode of death that has proved until now resistant to therapeutic intervention. In the GISSI (Gruppo Italiano per lo Studio della Sopravvivenza nellInfarto miocardico)-Prevenzione study, use of highly purified omega-3 polyunsaturated fatty acids (omega-3 PUFAs) at a dose of 1 g/day was associated with a substantial reduction in the all-cause mortality of post-MI patients. This reduction was the result of a large and statistically significant reduction in risk of sudden death, with these survival benefits emerging early in the course of the 3.5-year study and being additive to the benefits of conventional secondary preventive therapies. OMACOR, a pharmaceutical formulation of highly purified omega-3 PUFAs, has been approved for use in post-MI patients on the basis of the results of GISSI-Prevenzione.Several lines of evidence indicate that the clinical benefits of highly purified omega-3 PUFAs may be attributed to anti-arrhythmogenic qualities. Evidence for this mechanism of benefit is discussed in this review.OMACOR is an effective and well tolerated medication that complements established post-MI medications. This agent should be considered part of the standard treatment strategy for MI survivors.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201912040514756ZK.pdf | 293KB | download |