Arterial Stiffness: A Nexus between Cardiac and Renal Disease

Cardiorenal Medicine

Annayya R. Aroor¹  Guanghong Jia¹  James R. Sowers¹ 

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关键词: Cardiorenal metabolic syndrome;    Arterial stiffness;    Vascular smooth muscle cells;    Endothelial cells;    Estrogen;   

DOI  :  10.1159/000360867

来源: S Karger AG

【 摘 要 】

Vascular disease is the leading cause of morbidity and mortality in the Western world, and vascular function is determined by structural and functional properties of the arterial vascular wall. Cardiorenal metabolic syndrome such as obesity, diabetes, hypertension, kidney disease, and aging are conditions that predispose to arterial stiffening, which is a pathological alteration of the vascular wall and ultimately results in target organ damage in heart and kidney. In this review, we provide new insights on the interactions between arterial stiffness, vascular resistance and pulse wave velocity as well as final end-organ damage in heart and kidney. Better understanding of the mechanisms of arterial functional and hemodynamic alteration may help in developing more refined therapeutic strategies aimed to reduce cardiovascular and chronic kidney diseases.

【 授权许可】

Unknown