On- versus Off-Pump Coronary Artery Bypass Grafting: No Difference in Early Postoperative Kidney Function Based on TNF-α or C-Reactive Protein

Cardiorenal Medicine

Kazem Ghobadi¹  Amir Hamdi¹  Hassan Djavadzadegan¹  Nariman Nezami¹  Haleh Tabatabaie-Adl¹  Babak Hajhosseini¹  Sona Ghorashi¹ 

[1] $$

关键词: Coronary artery bypass grafting;    Renal function;    C-reactive protein;    Tumor necrosis factor-α;    On-pump;    Off-pump;    Cardiopulmonary bypass;    Cardiac surgery;   

DOI  :  10.1159/000339171

来源: S Karger AG

【 摘 要 】

Background/Aims: There are controversial data about renal function following off-pump coronary artery bypass grafting (CABG). The present study aimed to evaluate renal function changes 24 h after on- and off-pump CABG, as well as renal function correlated with high-sensitivity C-reactive protein (hs-CRP) and tumor necrosis factor-α (TNF-α). Methods: Ninety patients with coronary artery disease referred to our center for CABG from July 2006 to November 2007 were enrolled in the study. Patients were equally and randomly divided in two groups, on- and off-pump. Serum levels of creatinine (Cr), blood urea nitrogen, creatinine clearance (CrCl), hs-CRP, and TNF-α were determined immediately before and 24 h after surgery. Results: Cr and CrCl changes after surgery were not significantly different between the two groups; however, blood urea nitrogen levels after surgery were significantly higher in the on-pump group (p = 0.035). No statistically significant difference was noted between the two groups in terms of changes in levels of hs-CRP and TNF-α (p = 0.350 and 0.805, respectively). The changes in CrCl levels had no significant correlation with hs-CRP and TNF-α. Conclusions: The early Cr and CrCl levels after surgery are not significantly different in on- and off-pump groups. The early renal function after on- or off-pump CABG is not correlated with the levels of inflammatory markers including hs-CRP and TNF-α.

【 授权许可】

Unknown