期刊论文详细信息
Journal of Chemical Sciences
Synthesis and comparing the antibacterial activities of pyrimidine derivatives
S MOHAN32  B ANDREWS1 2 31  K KOMATHI32 
[1] PG and Research Department of Chemistry, Islamiah College, Vaniyambadi 635 752, India$$;Priyadarshini Engineering College, Vaniyambadi, Tamil Nadu, India$$
关键词: 5-amino thiadiazole;    5-amino triazole;    hydrazine carbothioamide;    pseudomonas aeruginosa;    staphylococcus aureus;    escherichia coli.;   
DOI  :  
来源: Indian Academy of Sciences
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【 摘 要 】

A series of 10 derivatives of 5-(5-amino-1,3,4-thiadiazole-2-yl)-3,4-dihydro-6-methyl-4-phenylpyrimidin-2(1H)-one and 10 derivatives of 3,4-dihydro-5-(5-mercapto-4H-1,2,4-triazol-3-yl)-6-methyl-4-phenyl pyrimidin-2(1H)-one have been synthesized. Among the synthesized derivatives, triazole substitutedcompounds have shown higher antibacterial inhibition when compared to the thiadiazole derivatives. All the structures of the newly synthesized compounds have been characterized by IR, 1H and 13C NMR, GC-MS and CHN analysis. Most of the compounds have shown promising antibacterial activity when compared with the standard drug ciprofloxacin.

【 授权许可】

Unknown   

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