An efficient PEG-400 mediated catalyst free green synthesis of 2-amino-thiazoles from α-diazoketones and thiourea

Journal of Chemical Sciences

B HARI BABU1¹  K VIJAY²  N SHARMILA¹  K BALA MURALI KRISHNA¹  M BABY RAMANA¹ 

[1] Department of Chemistry, Acharya Nagarjuna University, N Nagar, Andhra Pradesh, 522 510 India$$;College of Pharmaceutical Sciences, Acharya Nagarjuna University, N Nagar, Andhra Pradesh, 522 510 India$$

关键词: 2-amino thiazole;    α;    -diazoketone;    PEG-400;    green synthesis.;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

A simple and efficient method has been developed for the synthesis of 2-aminothiazoles from α-diazoketones using PEG-400 solvent system. This novel synthetic approach involves the reaction between thiourea and α-diazoketones in PEG-400 at 100 ◦C to yield the corresponding 2-aminothiazoles in good yields.The method is simple, rapid and generates thiazole derivatives in excellent yields without the use of any catalysts. This green protocol can be utilized for fast synthesis of various 2-aminothiazoles in good yields.

【 授权许可】

Unknown