Titanocene(III) chloride mediated radical induced addition-elimination route to the synthesis of racemic and optically active trisubstituted tetrahydrofurans: Formal synthesis of magnofargesin and 7'-epimagnofargesin

Journal of Chemical Sciences

S C ROY1¹  S K MANDAL²  P CHAKRABORTY¹ 

[1] Department of Organic Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700 032, India$$;Department of Chemistry, Saldiha College, Saldiha, Bankura 722 173, India$$

关键词: Titanocene(III) chloride;    radical;    tetrahydrofurans;    synthesis;    furano lignans.;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

Titanocene(III) Chloride mediated radical induced synthesis of 4-benzylidene substituted tetrahydrofuran, a typical lignan skeleton, has been accomplished in good yield through addition-elimination route in racemic as well as in optically active forms. The method has been applied to the synthesis of furano lignans, magnofargesin (1) and 7'-epimagnofargesin (2) in optically active forms.

【 授权许可】

Unknown