期刊论文详细信息
Journal of Chemical Sciences
An efficient synthesis of 8-substituted Odoratine derivatives by the Suzuki coupling reaction
Prasanta K Hota1  Avinash B Chaudhary2  Manoranjan Behera12  Jaya Shree A3  Murali B2  Balakrishna C2  Ravi Kumar P12  Satyanarayana Yennam2  Ramakrishna Gudipati2 
[1] Department of Chemistry, School of Sciences, HNBG University, Srinagar (Garhwal), Uttarakhand 246 174, India$$;Department of Medicinal Chemistry, GVK Biosciences Pvt. Ltd., Plot Nos 125(part) & 126, IDA, Mallapur, Hyderabad 500 076, Telangana, India$$;Centre for Chemical Sciences and Technology, Institute of Science and Technology, JNT University, Kukatpally, Hyderabad 500 085, Telangana, India$$
关键词: Odoratine;    suzuki coupling;    isoflavones;    fries rearrangement;    bromination;   
DOI  :  
来源: Indian Academy of Sciences
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【 摘 要 】

An efficient method for the preparation of 8-substituted odoratine [(3-(3', 4' -methylenedioxyphenyl)-5,6,7-trimethoxyisoflavone] derivatives, structurally similar to glaziovianin A, a known cytotoxic substance, has been described. The key steps in the synthesis are site selective bromination reaction followed by Suzuki coupling reaction in very good yield. The structural assignment of the bromo derivative was determined utilizing 2D-HMBC and NOEs NMR techniques.

【 授权许可】

Unknown   

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