Synthesis, DNA binding and cytotoxic evaluation of aminoquinoline scaffolds

Journal of Chemical Sciences

Mohamed Ashraf Ali2 3²  Gopal Senthil Kumar¹  Rajendra Prasad Karnam Jayarampillai1¹  Tan Soo Choon² 

[1] Department of Chemistry, Bharathiar University, Coimbatore 641046, India$$;Institute for Research in Molecular Medicine, Universiti Sains Malaysia, Minden 11800, Penang, Malaysia$$

关键词: Hydrazinylquinolines;    Isoindolin-1;    3-diones;    DNA binding;    cytotoxicity.;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

An effortless synthetic route has been developed for the synthesis of a new class of aminoquinoline substituted isoindolin-1,3-diones from regio-isomerical hydrazinylquinolines with phthalic anhydride in presence of Eaton’s reagent. DNA binding studies of selected isomeric compounds showed interaction withDNA via intercalation mode with higher binding affinity of 4-substituted quinolines rather than 2-substituted counterparts. Further, all compounds were screened for cytotoxic activity against three human cancer cell lines,among them compound 2c outranged standard doxorubicin against CCRF-CEM cell line.

【 授权许可】

Unknown