Unprecedented hetero-geometric discrete copper(II) complexes: Crystal structure and bio-mimicking of Catecholase activity

Journal of Chemical Sciences

ABHRANIL DE¹  ANGSHUMAN ROY CHOUDHURY²  R M KADAM⁴  DHANANJAY DEY¹  BHASKAR BISWAS1¹  HARE RAM YADAV²  VINAYAK RANE⁴  MILAN MAJI³ 

[1] Department of Chemistry, Raghunathpur College, Purulia, West Bengal, 723 133 India$$;Department of Chemical Sciences, Indian Institute of Science Education and Research Mohali, Sector 81, S A S Nagar, Manauli P. O. Mohali, Punjab, 140 306, India$$;Department of Chemistry, National Institute of Technology, Mahatma Gandhi Avenue, Durgapur, West Bengal, 713 209, India$$;Radiochemistry Division, Bhabha Atomic Research Centre, Trombay, Mumbai, Maharashtra 400 085, India$$

关键词: Copper;    X-ray structure;    radical activity;    catechol oxidase activity;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

An unprecedented solid of coper(II) complexes [Cu(dpa)₂NCS]₂[Cu(dpa)₂(NCS)₂](ClO₄)₂ (1) [dpa = 2,2'-dipyridylamine; SCN = thiocyanate], has been synthesized and crystallographically characterized with the aim to study the catecholase activity. The Cu(II) complex mimics the full catalytic cycle of the active site of catechol oxidase enzyme in acetonitrile medium with a turnover number of 4.788 × 10³ h⁻¹ along with the production of semiquinone radical and hydrogen peroxide. In situ generation of Cu(I) species in the catalytic pathway of catechol oxidation was established by electrochemical study and further confirmed by electron paramagnetic resonance (EPR) spectroscopy.

【 授权许可】

Unknown