Synthesis and antibacterial activity of new chiral 𝑁-sulfamoyloxazolidin-2-ones

Journal of Chemical Sciences

Billel Belhani²  Amel Bouaricha¹  Abdeslem Bouzina²  Fouzia Bouchareb²  Malika Berredjem1²  Nour-Eddine Aouf²  Samira Ait Kaki¹ 

[1] Laboratory of virology-bacteriology, University Hospital Center Touhami Benflis, Batna 05000 Algeria$$;Laboratory of Applied Organic Chemistry, Synthesis of Biomolecules and Molecular Modelling Group, Badji-Mokhtar, Annaba University, Box 12, 23000 Annaba, Algeria$$

关键词: Oxazolidinone;    chlorosulfonyl isocyanate;    sulfonamide;    antibacterial activity.;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

A new series of 𝑁, 𝑁′-bis-oxazolidinones-sulfone and 5-chloromethylsulfamoyl-oxazolidin-2-ones have been synthesized in three steps (carbamoylation, sulfamoylation and cyclization) starting from 1,3-dichloroporopan-2-ol, chlorosulfonyl isocyanate and primary or secondary amines. Synthesis has been carried out following simple methodology in excellent isolated yields. The structure and purity of the original compounds were confirmed by IR, NMR, and MS. The compounds were evaluated for their in vitro antibacterial activity against some Gram-positive bacteria; Staphylococcus aureus and Gram-negative bacteria; Escherichia Coli, Klebsiella pneumonieae, Acinetobacter, Pseudomonas aeruginosa, Enterococcus, Salmonella sp. The compounds showed moderate to good antibacterial activity.

【 授权许可】

Unknown