Access to new antimicrobial 4-methylumbelliferone derivatives

Journal of Chemical Sciences

Anis Romdhane1¹  Mejda Daami-Remadi²  Marwa Zayane¹  Hichem Ben Jannet¹ 

[1] Laboratoire de Chimie Hétérocyclique, Produits Naturels et Réactivité, Equipe: Chimie Médicinale et Produits Naturels, Faculté des Sciences de Monastir, Université de Monastir, Avenue de l’Environnement, 5019 Monastir, Tunisie$$;UR13AGR09, Production Horticole Intégrée au Centre Est Tunisien, Centre Régional des Recherches en Horticulture et Agriculture Biologique de Chott-Mariem, Université de Sousse, 4042, Chott-Mariem, Tunisie$$

关键词: 7-hydroxy-4-methyl-coumarin;    (4-methylumbelliferone);    imine;    triazole;    thiadiazole;    pyrazole;    pyrrole;    antimicrobial activity.;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

Synthesis of some novel coumarin esters has been accomplished through iodine-catalyzed method using 4-methylumbelliferone as the starting material. Condensation of hydrazide, which was obtained in two steps from 4-methylumbelliferone, with some arylaldhydes provided hydrazone derivatives, while the reaction with phenylthioisocyanate leads to the thiosemicarbazide that evolved into two new compounds. Finally, condensation reaction of hydrazide with three diketones afforded new pyrrole and pyrazole derivatives. Structures of all synthesized compounds were established on the basis of spectroscopic methods including 1H NMR, 13C NMR and ES-HRMS. They were finally tested for their antimicrobial activity and the structure-activity relationship was discussed.

【 授权许可】

Unknown