An efficient catalytic reductive amination: A facile one-pot access to 1,2-dihydropyrrolo[3,4-b]indol-3(4H)-ones by using B(C6F5)3/NaBH4

Journal of Chemical Sciences

Atulya Nagarsenkar¹  Nagendra Babu Bathini1¹  Santosh Kumar Prajapti¹ 

[1] Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Balanagar, Hyderabad 500037, India$$

关键词: Reductive amination;    Lewis acid;    tris(pentafluorophenyl)borane;    sodium borohydride;    less-toxic;    tandem reaction.;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

An efficient combination of B(C6F5)3 and NaBH4 was developed for direct reductive amination of aldehydes. A wide range of functional groups such as ester, nitro, nitrile, halogen, alkene, heterocycles were tolerated. Also, acid sensitive protecting groups like TBDMS and TBDPS were not affected. In addition, the present methodology was extended for tandem amination-amidation of 3-formyl-indole-2-carboxylic acids with substituted anilines to afford 1,2-dihydropyrrolo[3,4-b]indol-3(4H)-ones.

【 授权许可】

Unknown