Dithiocarbamate promoted practical synthesis of N-Aryl-2-aminobenzazoles: Synthesis of novel Aurora-A kinase inhibitor

Journal of Chemical Sciences

Kummari Srinivas¹  M Venkatanarayana¹  Naresh Kumar Katari1¹ 

[1] Department of Chemistry, HTP Campus, GITAM University, Rudraram, Hyderabad, Telangana 502 329, India$$

关键词: 2-Aminobenzoxazole;    2-Aminobenzothiazole;    Dithiocarbamate;    4-Aminoquinazoline Aurora kinase.;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

Various N-aryl-2-aminobenzoxazoles and N-aryl-2-aminobenzothiazoles were synthesized from o-aminophenol and o-aminothiophenol, respectively, mediated by dithiocarbamate in one step. The salient features of this method include mild reaction condition, high yield and large scale synthesis. Application of this methodology has been demonstrated by synthesizing potent Aurora kinase-A inhibitors.

【 授权许可】

Unknown