Synthesis of Novel 5-(𝑁-Substituted-Anilino)-8-Hydroxyquinolines via Hartwig-Buchwald Amination Reaction

Journal of Chemical Sciences

Osmo E O Hormi¹  Walaa A E Omar1 2¹ 

[1] Department of Chemistry, University of Oulu, P.O. Box 3000, FI-90014 Oulu, Finland$$

关键词: Hartwig–Buchwald amination;    electron-rich phosphine ligands;    5-anilino-8-hydroxyquinoline;    1;    2;    3;    4-tetrahydroquinolin-8-ol;    catalytic hydrogenation.;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

Three novel 5-(𝑁-substituted-anilino)-8-benzyloxyquinoline derivatives were efficiently synthesized via Hartwig–Buchwald amination reaction. The new 5-(𝑁-substituted-anilino)-8-benzyloxyquinolines were reduced for 1–3 h to give the corresponding 5-(𝑁-substituted-anilino)-8-hydroxyquinolines. Extending the reduction reaction time to 7 h afforded the corresponding 1,2,3,4-tetrahydro-8-hydroxyquinoline derivatives.

【 授权许可】

Unknown