Ultrasound promoted and SiO2/CCl3COOH mediated synthesis of 2-aryl-1-arylmethyl-1𝐻-benzimidazole derivatives in aqueous media: An eco-friendly approach

Journal of Chemical Sciences

Luis Cumbal³  Brajesh Kumar1 2²  Brajendra Kumar¹  Kumari Smita³ 

[1] Department of Computer Science and Engineering, National Institute of Technology, Durgapur, West Bengal, 713 209, India$$;Department of Chemistry, TATA College, Kolhan University, Chaibasa, Jharkhand, 833 202, India$$;Centro de Nanociencia y Nanotecnologia, Universidad de las Fuerzas Armadas -ESPE, Av. Gral. Rumiñahui s/n, Sangolqui, P.O. BOX 171-5-231B, Ecuador$$

关键词: 2-Aryl-1-arylmethyl-1H-benzimidazoles;    silica gel supported trichloroacetic acid (SiTCA);    regioselective;    one-pot synthesis;    ultrasound irradiation.;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

Ultrasonic irradiation is an efficient and innocuous technique of reagent activation for synthesizing organic compounds. First one-pot synthesis of 2-aryl-1-arylmethyl-1H- benzimidazole derivatives from o- phenylenediamine and an aromatic aldehyde in the presence of silica gel supported trichloroacetic acid (SiTCA) was carried out with excellent yields at 50°C by sonication. This method provided several advantages such as green solvent, inexpensive catalyst, simple experimental methodology, shorter reaction time and higher yield.

【 授权许可】

Unknown