Design, synthesis and characterization of 1𝐻-pyridin-4-yl-3,5-disubstituted indazoles and their AKT inhibition activity

Journal of Chemical Sciences

Arava Veera Reddy1³  P K Dubey²  Arunasree M Kalle¹  Surendrareddy Gogireddy³ 

[1] Department of Animal Sciences, School of Life Sciences, University of Hyderabad, Hyderabad 500 046, India$$;Department of Chemistry, J N T University, Hyderabad 500 072, India$$;R&D Centre, Suven Life Sciences Ltd., Plot No. #18, Phase-III, Jeedimetla, Hyderabad 500 055, India$$

关键词: 1𝐻-pyridin-4-yl-3;    5-disubstituted indazoles;    Suzuki reaction;    Akt kinase activity.;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

A new series of 1𝐻-pyridin-4-yl-3,5-disubstituted indazoles and their derivatives were synthesized by the reaction of 5-Bromo-1-(2-cyano-pyridin-4-yl)-1𝐻-indazole-3-carboxylic acid diethylamide with aryl boronic acids by Suzuki coupling reaction in the presence of Pd(OAc)2 and CsF. All the new compounds have been characterized by spectral data. The title compounds were subsequently evaluated for their Akt kinase activity.

【 授权许可】

Unknown