Design, synthesis and cytotoxicity of novel N-benzylpiperidin-4-one oximes on human cervical cancer cells

Journal of Chemical Sciences

Someshwar D Dindulkar1³  Paramasivam Parthiban²  Vedavati G Puranik⁵  Yeon Tae Jeong1³  Ira Bhatnagar⁴  Rupesh L Gawade⁵  Se-Kwon Kim³  Dong Hyun Anh¹ 

[1] Department of Food Science and Technology, Pukyong National University, Busan 608 737, Republic of Korea$$;Department of Chemistry, Veltech Multitech Dr. Rangarajan Dr. Sakunthala Engineering College, Chennai 600 062, India$$;Department of Image Science and Engineering, Pukyong National University, Busan 608 737, Republic of Korea$$;Nanotheranostics Laboratory, Centre for Cellular and Molecular Biology, Hyderabad 500 007, India$$;Center for Materials Characterization, National Chemical Laboratory, Pune 400 008, India$$

关键词: N-benzylpiperidin-4-one oximes;    cytotoxicity;    HeLa cells;    single-crystal XRD.;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

A series of fifteen diversified N-benzylpiperidin-4-one oximes were synthesized and characterized by their NMR spectral data. Additionally, single-crystal XRD analysis was performed for the representative symmetrically and unsymmetrically substituted molecules. All the synthesized oximes from unsymmetrical ketones existed as E-isomer as witnessed by their NMR and XRD data. Among the synthesized target compounds that evaluated for their in vitro cytotoxicity against human cervical carcinoma (HeLa) cells, five compounds were potent with IC50 < 17 𝜇M. 1-Benzyl-2,6-bis(4-isopropylphenyl)-3-methylpiperidin-4-one oxime 3c with an IC50 of 13.88 𝜇M was found to be the best active compound as depicted by the microscopic analysis.

【 授权许可】

Unknown