Pd(OAc)2/DPPF-catalysed microwave-assisted cyanide-free synthesis of aryl nitriles

Journal of Chemical Sciences

Bhalchandra M Bhanage1¹  Dinesh N Sawant¹ 

[1] Department of Chemistry, Institute of Chemical Technology, Matunga, Mumbai 400 019, India$$

关键词: Cyanation;    benzonitrile;    palladium;    cyanide-free;    C-C coupling;    1;    3-diketones;    amines;    ionic liquids.;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

This study reports microwave-assisted cyanide-free synthesis of aryl nitriles from aryl halides using palladium acetate/1,1-bis(diphenylphosphino)ferrocene as a new catalyst system. Reported protocol is a rapid, cyanide-free, single step reaction, wherein formamide acts as a solvent as well as a source of cyanide. The use of microwave increases the rate of reaction substantially and it was observed that aryl nitriles can be synthesised in 50 min of microwave irradiation compared to conventional thermal heating protocol which requires 48 h.

【 授权许可】

Unknown