An easy protocol for the domino synthesis of diversely functionalized spirocarbocycles and their biological evaluation

Journal of Chemical Sciences

C Balachandran²  Paramasivan T Perumal1¹  Selvarangam E Kiruthika¹  S Ignacimuthu² 

[1] Organic Chemistry Division, CSIR-Central Leather Research Institute, Adyar, Chennai 600 020, India$$;Division of Microbiology, Entomology Research Institute, Loyola College, Chennai 600 034, India$$

关键词: Spirocarbocycles;    L-proline;    vinyl malononitriles;    chalcones;    antimicrobial activity.;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

A base-catalysed domino reaction for the synthesis of spirocarbocycles in excellent yields using chalcones and vinyl malononitriles is reported. This consists of a series of steps including Knoevenagel condensation followed by intermolecular vinylogous Michael addition and intramolecular cyclization. The synthesized compounds were evaluated for their antimicrobial activity and the compounds exhibited moderate to excellent activities.

【 授权许可】

Unknown