Signal amplification of dopamine using lanthanum hexacyanoferrate-modified electrode

Journal of Chemical Sciences

T Selvaraju1 2¹  R Ramaraj¹ 

[1]Centre for Photoelectrochemistry, School of Chemistry, Madurai Kamaraj University, Madurai 625 021, India$$

关键词: Lanthanum hexacyanoferrate-modified electrode;    dopamine;    ascorbic acid;    signal amplification;    real sample analysis.;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

A sensitive and selective electrochemical sensor has been developed using an electroactive polynuclear lanthanum hexacyanoferrate (LaHCF) complex with counter alkali cation (Na+) deposited on the glassy carbon (GC) electrode (GC/LaHCF). The GC/LaHCF-modified electrode is found to be an excellent transducer in mediating the oxidation of neurotransmitter molecule such as dopamine (DA) at physiological pH 7.2. Interestingly, the GC/LaHCF-modified electrode amplifies a 50-fold enhancement in the oxidation of DA signal compared to the bare GC electrode. Besides, the GC/LaHCF-modified electrode shows excellent selectivity in the voltammetric oxidation of DA in the presence of ascorbic acid (AA). Under optimal conditions, the GC/LaHCF modified electrode shows a linear relationship in DA oxidation between 0.1 × 10−6 and 1.0 × 10−6M with the detection limit of 1 × 10−8M (10 nM). Importantly, practical utility of the modified electrode is good in studying the real sample analysis such as dopamine hydrochloride injection assay.

【 授权许可】

Unknown