Zn(OTf)2-catalysed indolylation and pyrrolylation of isatins: Efficient synthesis and biochemical assay of 3,3-di(heteroaryl)oxindoles

Journal of Chemical Sciences

C Praveen¹  P Dheenkumar1¹  P T Perumal1¹  S Narendiran² 

[1] Organic Chemistry Division, Central Leather Research Institute (CSIR), Adyar, Chennai 600 020, India$$;Department of Pharmaceutical Chemistry, Sri Venkateswara College of Pharmacy, Chitoor 517 127, India$$

关键词: Zn(OTf)2;    3;    3-di(indolyl)oxindoles;    3;    3-di(pyrrolyl)oxindoles;    serum glutamate oxaloacetate transaminase (SGOT);    malondialdehyde (MDA).;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

An efficient and cheap synthetic approach to 3,3-di(indolyl)oxindoles and 3,3-di(pyrrolyl) oxindoles has been developed via Zn(OTf)2 catalysed indolylation and pyrrolylation of isatins. A preliminary biochemical assay of the synthesized molecules in rodent models were performed to estimate the serum glutamate oxaloacetate transaminase and malondialdehyde levels.

【 授权许可】

Unknown