The reaction of carbon disulphide with 𝛼-haloketones and primary amines in the presence of potassium iodide as catalyst

Journal of Chemical Sciences

Fariba Salimi¹  Ali Ramazani²  Javad Safaei-Ghomi1¹ 

[1] Department of Chemistry, Faculty of Sciences, University of Kashan, Kashan, 51167, IR, Iran$$;Chemistry Department, Zanjan University, P O Box 45195-313, Zanjan, Ira$$

关键词: carbon disulphide;    𝛼-haloketone;    primary amines;    potassium iodide;    thiazole;    nucleophilic addition.;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

A simple, mild and convenient method has been developed for the synthesis of 3,4,5-trialkyl-1,3-thiazole-2(3𝐻)-thione derivatives through one pot three-component reaction between a primary amine, carbon disulphide, and 𝛼-haloketone in the presence of potassium iodide at room temperature conditions. The products were obtained with excellent yield and appropriate reaction times. This reaction represents a rapid and unprecedented route to the described molecules that have biological specifications.

【 授权许可】

Unknown