Synthesis of some novel fluoro isoxazolidine and isoxazoline derivatives using 𝑁-benzyl fluoro nitrone via cycloaddition reaction in ionic liquid

Journal of Chemical Sciences

Govinda Prasad Luitel¹  Bhaskar Chakraborty1¹ 

[1] Organic Chemistry Laboratory, Sikkim Government College, Gangtok 737 102, India$$

关键词: 𝑁-Benzyl fluoro nitrone;    cycloaddition reaction;    fluoro isoxazolidine and isoxazolines;    ionic liquid;    1;    3-amino alcohol;    aldehyde/ketone synthesis.;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

1-Butyl-3-methylimidazolium-based ionic liquids are found to accelerate significantly the intermolecular 1,3-dipolar cycloaddition of 𝑁-benzyl-fluoro nitrone derived in situ from 2,6-difluoro benzaldehyde and 𝑁-benzylhydroxylamine, with activated alkenes and electron deficient alkynes to afford enhanced rates and improved yields of novel isoxazolidines and isoxazolines.

【 授权许可】

Unknown