TMSCl-catalysed condensation of 𝛼-diketone compounds with urea/thiourea derivatives under solvent-free conditions

Journal of Chemical Sciences

Alireza Khajeh Amiri¹  Akbar Mobinikhaledi1¹ 

[1] Department of Chemistry, Faculty of Science, Arak University, P.O. Box 14335-186, Arak, Iran$$

关键词: TMSCl;    solvent-free;    green chemistry;    glycoluril;    imidazolidine-2-one;    imidazole-2-thiol.;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

An efficient, rapid and green synthesis of glycoluril, imidazolidine-2-one, imidazole-2-one and imidazole-2-thiol derivatives have been accomplished by the reaction of urea/thiourea derivatives and 𝛼-diketone at 100°C in the presence of trimethylsilyl chloride (TMSCl) as Lewis acid catalyst under solvent-free conditions. This approach offers many advantages such as good product yields, various products, short reaction time, easy isolation of products, facile purification and environmentally benign reaction conditions.

【 授权许可】

Unknown