Synthesis of spiro[pyrazolo[3,4-ð?‘?] pyridine-4,3'-indoline] and spiro [benzo[â„Ž]pyrazolo[3,4-ð?‘?]quinoline-4,3'-indoline] derivatives using wet cyanuric chloride under solvent-free conditions

Journal of Chemical Sciences

Zhikui Yin¹  Limin Yang¹  Liqiang Wu1¹ 

[1] School of Pharmacy, Xinxiang Medical University, Xinxiang, Henan 453003, China$$

关键词: Cyanuric chloride;    spiro[benzo[â„Ž]pyrazolo[3;    4-ð?‘?]quinoline-4;    3'-indoline];    spiro[pyrazolo[3;    4-ð?‘?] pyridine-4;    3'-indoline];    solvent-free;    green synthesis.;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

A simple and efficient synthesis of spiro[pyrazolo[3,4-𝑏]pyridine-4,3'-indoline] and spiro[benzo[ℎ] pyrazolo[3,4-𝑏]quinoline-4,3'-indoline] derivatives has been accomplished by the one-pot condensation of isatins, 3-methyl-1-phenyl-1𝐻-pyrazol-5- amine and Meldrum’s acid or 2-hydroxy-1,4-naphthoquinone in the presence of wet cyanuric chloride as a catalyst under solvent-free conditions.

【 授权许可】

Unknown