Synthesis of new series of 3-hydroxy/acetoxy-2-phenyl-4𝐻-chromen-4-ones and their biological importance

Journal of Chemical Sciences

Harjeet Juneja²  Mangesh Gharpure1²  Vishwas Ingle²  Ratiram Choudhary¹ 

[1]Department of Chemistry, Seth Kesarimal Porwal College, Kamptee 441 002, India$$

[2]Department of Chemistry, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur 440 033, India$$

关键词: Chalcones;    flavones;    acetoxy ester;    microwave irradiation;    antimicrobial;    X-ray crystal structure.;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

3-Hydroxy-2-aryl/heteroaryl-4𝐻-chromones 4(a-n) were synthesized from appropriate chalcones 3(a-n) and acetylated to afford the corresponding acetoxy derivatives 5(a-n). All compounds were evaluated for antimicrobial activity against Staphylococus aureus, Bacillus subtillis, Escherichia coli and Pseudomonas aeruginosa as well as fungi e.g., Candida albicans and Aspergius niger. Inhibition caused by hydroxy flavones was relatively low, whereas that of their acetoxy ester analogues was substantially high. Structure of 6-chloro-2-(furan-2-yl)-4-oxo-4𝐻-chromen-3-yl acetate (5j) was also supported by means of single crystal X-ray diffraction.

【 授权许可】

Unknown