Mannich reaction: A versatile and convenient approach to bioactive skeletons

Journal of Chemical Sciences

Selva Ganesan Subramaniapillai1¹ 

[1] School of Chemical and Biotechnology, SASTRA University, Thanjavur-613 401, India$$

关键词: Mannich reaction;    Mannich bases;    bioactive molecules;    antimalarial;    antitumour;    antitubercular.;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

This review gives an insight into the recent applications of Mannich reaction and its variants in the construction of bioactive molecules. Emphasis is given to the Mannich reaction that provides bioactive molecules and/or modifies the property of an existing bioactive molecule. The role of Mannich reaction in the construction of antimalarial, antitumour, antimicrobial, antitubercular, antiinflammatory and anticonvulsant molecules and also the significance of aminoalkyl Mannich side chain on the biological property of molecules is discussed here.

【 授权许可】

Unknown