Role of 𝑁-methyl-8-(alkoxy)quinolinium iodide in suppression of protein-protein interactions

Journal of Chemical Sciences

Bimlesh Ojha¹  Gopal Das1¹  Cirantan Kar¹ 

[1] Department of Chemistry, Indian Institute of Technology Guwahati, Assam 781 039, India$$

关键词: Inhibitors;    amyloid;    protein;    aggregation;    conformation;    HEWL.;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

There is a great deal of interest in developing small molecule inhibitors of protein misfolding and aggregation due to a growing number of pathologic states known as amyloid disorders. In searching for alternative ways to reduce protein-protein interactions or to inhibit the amyloid formation, the inhibitory effects of cationic amphiphile viz. 𝑁-methyl-8-(alkoxy)quinolinium iodide on aggregation behaviour of hen egg white lysozyme (HEWL) at alkaline pH has been studied. Even though the compounds did not protect native HEWL from conformational changes, they were effective in diminishing HEWL amyloid formation, delaying both nucleation and elongation phases. It is likely that strong binding in the HEWL compound complex, raises the activation energy barrier for protein misfolding and subsequent aggregation, thereby retarding the aggregation kinetics substantially.

【 授权许可】

Unknown