Heterocyclyl linked anilines and benzaldehydes as precursors for biologically significant new chemical entities

Journal of Chemical Sciences

Vijay Kumar¹  Prithwish Ghosh¹  Lalit K Wadhwa²  Raman K Verma1¹ 

[1] Synthetic Organic and Medicinal Chemistry Laboratory, Department of Chemistry, Punjabi University, Patiala 147 002, India$$;Ind-Swift Laboratories Limited (Research and Development Centre), Plot No. E-5, Industrial Area, Phase-2, SAS Nagar, Mohali 160 055, India$$

关键词: Benzimidazole;    indole;    acridone;    benzaldehyde;    aniline.;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

Benzylidene and benzyl thiazolidinediones, oxazolidinediones, isoxazolidinediones and their acyclic analogs like alpha alkylthio/alkoxy phenylpropanoic acids, beta-keto esters and tyrosine-based compounds possess broad therapeutic potential in general and as Peroxisome Proliferator Activated Receptors (PPARs) agonists in particular in the management of hyperglycemia and hyperlipidaemia for the treatment of Type 2 Diabetes (T2D). We have synthesised and characterized some novel and suitably substituted heterocyclyl linked benzaldehydes and anilines, which can be easily and very readily derivatized to all the above mentioned classes to generate new chemical entities of broader biological significance. Synthesis of their benzylidene thiazolidinedione and diethyl malonate and also benzyl diethyl malonate and alpha-bromoesters derivatives is reported in some of the cases in the present work.

【 授权许可】

Unknown