Mechanistic aspects of Os(VIII) catalysed oxidation of loop diuretic drug furosemide by Ag(III) periodate complex in aqueous alkaline medium

Journal of Chemical Sciences

Sharanappa T Nandibewoor¹  Shweta J Malode¹  Nagaraj P Shetti¹ 

[1] Post-Graduate Department of Studies in Chemistry, Karnatak University, Dharwad 580 003, India$$

关键词: Kinetics;    oxidation;    diperiodatoargentate(III);    furosemide;    Os(VIII) catalysis;    mechanism.;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

The kinetics of oxidation of a loop diuretic drug furosemide (Fur) by diperiodatoargentate(III) (DPA) has been investigated in the presence of osmium(VIII) (Os(VIII)) used as homogeneous catalyst in alkaline medium at a constant ionic strength of 0.20mol dm-3 spectrophotometrically attached with HI-TECH SFA-12 stopped flow accessory. The stoichiometry was 1:2 (Fur:DPA). The order of the reaction with respect to [DPA] was unity while the order with respect to [Fur] was less than unity over the concentration range studied. The rate increased with an increase in [OH−] and decreased with an increase in [IO$^{−}_{4}$]. The order with respect to [Os(VIII)] was unity. The oxidation products were identified as 2-(4-carboxy-2-oxo-but-3-enylamino)-4-chloro-5-sulfamoyl-benzoic acid and Ag(I). A suitable mechanism was proposed. The reaction constants involved in the different steps of the reaction mechanism were calculated. Kinetic experiments suggest that [Ag(H2IO6)(H2O)2] is the reactive silver(III) species and [OsO4(OH)2]2− is the reactive Os(VIII) species.

【 授权许可】

Unknown