Journal of Chemical Sciences | |
Understanding proton affinity of tyrosine sidechain in hydrophobic confinement | |
S Taraphder1  T Karmakar1  T G Abi11  | |
[1] Department of Chemistry, Indian Institute of Technology Kharagpur, Kharagpur 721 302, India$$ | |
关键词: Tyrosine; proton affinity; carbon nanotube.; | |
DOI : | |
来源: Indian Academy of Sciences | |
【 摘 要 】
Tyrosine is an important amino acid residue that plays a key role in several biochemical transformations such as, abstraction/donation of proton from/by its sidechain. We present here a density functional study on the proton affinity of tyrosine sidechain suspended inside the core of a single walled carbon nanotube that mimics the environment of protein structural pores and molecular channels. Tyrosine is found to exhibit a lower reactivity on confinement and unlike several other polar amino acid sidechains, its reactivity does not respond to hydrogen bonding with neighbouring hydroxyl groups.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201912040508325ZK.pdf | 285KB | download |