Simple and efficient Knoevenagel synthesis of (𝐸)-2-((1H-indol-3-yl) methylene)-3-oxoindolylnitrile catalysed by PPh3

Journal of Chemical Sciences

M Venkatanarayana1¹  P K Dubey¹ 

[1] Department of Chemistry, Jawaharlal Nehru Technological University, Hyderabad College of Engineering, Kukatpally, Hyderabad 500 085, India$$

关键词: Indole-3-aldehydes;    3-cyanoacetylindole;    PPh3;    Ethanol;    PEG-600;    DMS.;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

Triphenylphosphine (TPP) is found to be an efficient catalyst for the Knoevenagel condensation of indole-3-carboxyaldehydes 1(a-e) and their 𝑁-substituted derivatives 4(a-e) with the active methylene compound, i.e., 3-cyanoacetylindole (2), affording novel substituted olefins 3(a-e) and 5(a-e) respectively. The latter products reacted with DMS in the presence of PEG-600 to afford the corresponding N, N1 dimethylated derivatives 6(a-e).

【 授权许可】

Unknown