期刊论文详细信息
Journal of Chemical Sciences | |
Simple and efficient Knoevenagel synthesis of (ð¸)-2-((1H-indol-3-yl) methylene)-3-oxoindolylnitrile catalysed by PPh3 | |
M Venkatanarayana11  P K Dubey1  | |
[1] Department of Chemistry, Jawaharlal Nehru Technological University, Hyderabad College of Engineering, Kukatpally, Hyderabad 500 085, India$$ | |
关键词: Indole-3-aldehydes; 3-cyanoacetylindole; PPh3; Ethanol; PEG-600; DMS.; | |
DOI : | |
来源: Indian Academy of Sciences | |
【 摘 要 】
Triphenylphosphine (TPP) is found to be an efficient catalyst for the Knoevenagel condensation of indole-3-carboxyaldehydes 1(a-e) and their ð‘-substituted derivatives 4(a-e) with the active methylene compound, i.e., 3-cyanoacetylindole (2), affording novel substituted olefins 3(a-e) and 5(a-e) respectively. The latter products reacted with DMS in the presence of PEG-600 to afford the corresponding N, N1 dimethylated derivatives 6(a-e).
【 授权许可】
Unknown
【 预 览 】
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