Synthesis of 4-aryl-4,5-dihydro-1𝐻-indeno[1,2-𝑑]pyrimidines by Biginelli condensation and their antibacterial activities

Journal of Chemical Sciences

Aruna Bhatia²  Balbir Kaur1¹  Tulika Mishra²  Ramandeep Kaur¹  Monika Bansal¹ 

[1] Department of Chemistry, Punjabi University, Patiala 147002, India$$;Department of Biotechnology, Punjabi University, Patiala 147002, India$$

关键词: Indeno[1;    2-𝑑]pyrimidine-2-thiones;    multicomponent reaction;    microwave irradiation;    antibacterial activity.;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

A simple and efficient method has been developed for the synthesis of series of 4-aryl-1,3,4,5-tetrahydro-2𝐻-indeno[1,2-𝑑]pyrimidine-2-thiones through Biginelli’s one-pot multicomponent condensation reaction via microwave irradiations. Then, these thiones were converted to their S-alkylated/aralkylated derivatives. The prepared heterocyclic products were structurally confirmed by analytical and spectral data and evaluated for their antibacterial activities. The results showed that this skeletal framework exhibited marked potency as antibacterial agents. The compound 2-(Ethylthio)-4-(4-Hydroxy-3-methoxyphenyl)-4,5-dihydro-1𝐻-indeno[1,2-𝑑]pyrimidines 4b have shown antibacterial activity towards all the seven clinical isolates used.

【 授权许可】

Unknown