Voltammetric determination of theophylline at a Nafion/multi-wall carbon nanotubes composite film-modified glassy carbon electrode

Journal of Chemical Sciences

Jianjun Li¹  Gang Li²  Suling Yang¹  Lingbo Qu1 3 2¹  Ran Yang¹ 

[1] Department of Chemistry, Zhengzhou University, Zhengzhou 450001, P.R. China$$;College of Chemistry and Chemical Engineering, Anyang Normal University, Anyang 455002, P.R. China$$

关键词: Theophylline;    Nafion;    multi-wall carbon nanotubes;    voltammetry.;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

A Nafion/multi-wall carbon nanotubes (MWNTs) composite film-modified electrode was fabricated and applied to the sensitive and convenient determination of theophylline (TP). Multi-wall carbon nanotubes (MWNTs) were easily dispersed homogeneously into 0.1% Nafion methanol solution by sonication. Appropriate amount of Nafion/MWNTs suspension was coated on a glassy carbon electrode. After evaporating methanol, a Nafion/MWNTs composite film-modified electrode was achieved. TP could effectively accumulate at Nafion/MWNTs composite film-modified electrode and cause a sensitive anodic peak at around 1180 mV (vs SCE) in 0.01 mol/L H2SO4 medium (pH 1.8). In contrast with the bare glassy carbon electrode, Nafion film-modified electrode, Nafion/MWNTs film-modified electrode could remarkably increase the anodic peak current and decreased the overpotential of TP oxidation. Under the optimized conditions, the anodic peak current was proportional to TP concentration in the range of 8.0 × 10-8-6.0 × 10-5 mol/L, with a detection limit of 2.0 × 10-8 mol/L. This newly developed method was used to determine TP in drug samples with good percentage of recoveries.

【 授权许可】

Unknown