Palladium-catalysed ortho arylation of acetanilides

Journal of Chemical Sciences

Xin-Hua Feng¹  Guo-Sheng Huang1¹  Guo-zhen zhang¹  Cheng-Qun Chen¹ 

[1] State Key Laboratory of Applied Organic Chemistry, Lanzhou 73000, P.R. China$$

关键词: Palladium;    acetanilides;    C-H activation;    aryl iodides;    2-arylacetanilides;    2;    6-diarylacetanilides.;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

The palladium-catalysed direct arylation of acetanilides by using C-H activation methodology has been demonstrated. Several acetanilides were coupled with aryl iodides in the presence of 10 mol% of Pd(OAc)2, 1.0 equiv of Cu(OTf)2, and 0.6 equiv of Ag2O to afford the corresponding products in moderate to excellent yields. The results showed that the amount of Ag2O was important for this protocol.

【 授权许可】

Unknown