Emerging trends at the interface of chemistry and biology: Applications to the design of human therapeutics

Journal of Chemical Sciences

Santanu Bhattacharya1²  Raghavan Varadarajan2¹ 

[1]Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560 012$$

[2]Department of Organic Chemistry, Indian Institute of Science, Bangalore 560 012$$

关键词: Multi-target therapeutics;    network biology;    gene delivery;    protein therapeutics;    protein design.;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

This article describes recent developments in the design and implementation of various strategies towards the development of novel therapeutics using first principles from biology and chemistry. Strategies for multi-target therapeutics and network analysis with a focus on cancer and HIV are discussed. Methods for gene and siRNA delivery are presented along with challenges and opportunities for siRNA therapeutics. Advances in protein design methodology and screening are described, with a focus on their application to the design of antibody based therapeutics. Future advances in this area relevant to vaccine design are also mentioned.

【 授权许可】

Unknown