Synthesis, antimicrobial activity of lamotrigine and its ammonium derivatives

Journal of Chemical Sciences

Yong Qian¹  Zhong-Cheng Song¹  Lei Shi¹  Peng-Cheng Lv¹  Hai-Liang Zhu1¹  Rui-Qin Fang¹ 

[1] State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People’s Republic of China$$

关键词: Lamotrigine;    ammonium;    crystal structure;    antibacterial activity.;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

Antiepileptic drug lamotrigine and its thirteen ammonium salt complexes (4a-4m) were synthesized and characterized by IR, elemental analysis, 1H-NMR, and MS spectral methods. Many of the ammonium salts (4a-4m) were first reported. Furthermore, the crystal structure of compound 3 was determined by single crystal X-ray diffraction analysis. All these complexes were tested in vitro for their antibacterial activity (Bacillus subtilis, Staphylococcus aureus, Enterococus faecalis, Escherichia coli, Pseudomonas aeruginosa and Enterobacter cloacae). The results indicated that most of the complexes showed good antibacterial activity against Gram-positive (B. subtilis, S. aureus and S. faecalis), but showed mild, even inactive against Gram-negative bacterial strains.

【 授权许可】

Unknown