Solvent effects in the reaction between piperazine and benzyl bromide

Journal of Chemical Sciences

S Ranga Reddy¹  P Manikyamba1¹ 

[1] Department of Chemistry, Kakatiya University, Warangal 506 009$$

关键词: Solvation;    solvent electrophilicity;    hydrogen bond donor ability;    linear solvation energy relationship (LSER).;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

The reaction between piperazine and benzyl bromide was studied conductometrically and the second order rate constants were computed. These rate constants determined in 12 different protic and aprotic solvents indicate that the rate of the reaction is influenced by electrophilicity (𝐸), hydrogen bond donor ability (𝛼) and dipolarity/polarizability (𝜋*) of the solvent. The LSER derived from the statistical analysis indicates that the transition state is more solvated than the reactants due to hydrogen bond donation and polarizability of the solvent while the reactant is more solvated than the transition state due to electrophilicity of the solvent. Study of the reaction in methanol, dimethyl formamide mixtures suggests that the rate is maximum when dipolar interactions between the two solvents are maximum.

【 授权许可】

Unknown