Microwave-mediated reductive amination-cyclization of 4-aryl-4-oxobutanoates: Facile synthesis of 3-methylidene-5-phenyl-2,3-dihydropyrrolidones

Journal of Chemical Sciences

S P Senthilkumar¹  H Surya Prakash Rao1¹ 

[1] Department of Chemistry, Pondicherry University, Pondicherry 605 014, India$$

关键词: Microwaves;    three-component coupling;    pyrrolidones;    ammonium formate.;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

Microwave-mediated three-component condensation of 4-aryl-4-oxobutanoates with ammonium formate furnishes 3-methylidene-5-phenyl-2,3-dihydropyrrolidones in good yield within 2 min. The pyrrolidone products were characterized on the basis of spectral data and X-ray crystal structure analysis. The reaction is found to be general and a variation in the ester and aryl moieties is possible. However, when alkylammonium formate is used only amide products are formed.

【 授权许可】

Unknown